Drug discovery constitutes a significant part of the research that is carried out by scientists daily. It is hoped that the continual investment of time, resources and energy into this type of work might one day lead to the creation of world-leading drugs to combat illnesses such as cancer.
Peptide hydrogels play a significant part in this journey and are helping researchers to make vast and significant steps that may get them just that little bit closer to making these important and life-changing discoveries. Manchester Biogel looks at this journey in more detail.
Projects Involving Peptide Hydrogels
PeptiGels® (peptide hydrogels) have already been used successfully by a research group at Imperial College London who wanted to mimic the chemical and mechanical environment of both cancer and healthy tissue. The results of their research indicated that PeptiGels® mimicked the environment of both the healthy and cancer cells, resulting in a biomechanical response of increased expression of Ki67 in the PDAC suit-2 cells.
A research group has also used them at the University of Manchester to research the field of breast cancer cells and tumours. The group used PeptiGels® to support the growth of a 3D tumour model that used MCF-7 breast cancer cells, MSC and HUVEC cells. When it comes to looking for products, animal-free PeptiGels® provide a promising solution for the study of 3D in-vitro tumour models, with applications in drug discovery.
These two research projects by well-respected research groups have shown that in the field of drug discovery, PeptiGels® have a significant impact. With promising results on all fronts that have implications for future research into cancer cells and tumours, peptide hydrogels could help lead to further important research projects.
What can Peptide Hydrogels do?
Peptide hydrogels are a fully synthetic product that has already been proven to be incredibly successful in supporting several different cancer applications. Their makeup allows them to be fine-tuned both mechanically and functionally to create an in vitro environment that can mimic the in-vivo and any human tissue.
PeptiGels® are supplied in a ready to use format and are chemically defined with no variability from one batch to another. Because there is no variability, you can be confident that the results you will get will be reliable and reproducible. This is fantastic news for researchers, whatever their field, as it means that they can have confidence in their results whilst saving resources and time.
What are the future benefits?
The future benefits of PeptiGels® are only just beginning to be discovered, but one thing is clear from all of the research that they have been involved in, and that is that there are significant breakthroughs to be made in the future.
The Imperial College London research has shown that PeptiGel® matrices can open up the potential for further investigation into details of mechanotransduction signalling pathways affected by the activation and survival of cancer cells. The extensive research into breast cancer cells and tumours that is ongoing at the University of Manchester shows just what a promising influence PeptiGels® can have when it comes to consistent results from one sample to another and over a period of time.
The make-up of PeptiGels® has made research that little bit easier for scientists as they continue their research into understanding cancer and searching for some answers as to how to combat such illnesses.